Marc A Seelen Selected Research

Brain Death (Brain Dead)

1/2021	Brain death-induced lung injury is complement dependent, with a primary role for the classical/lectin pathway.
1/2019	Blocking Complement Factor B Activation Reduces Renal Injury and Inflammation in a Rat Brain Death Model.
1/2018	C1-Inhibitor Treatment Decreases Renal Injury in an Established Brain-Dead Rat Model.
1/2017	Complement in renal transplantation: The road to translation.
1/2017	Complement-mediated inflammation and injury in brain dead organ donors.
6/2015	Hypoxia and Complement-and-Coagulation Pathways in the Deceased Organ Donor as the Major Target for Intervention to Improve Renal Allograft Outcome.
2/2012	Lectin complement pathway gene profile of the donor and recipient does not influence graft outcome after kidney transplantation.
7/2011	Systemic complement activation in deceased donors is associated with acute rejection after renal transplantation in the recipient.
7/2011	Local renal complement C3 induction by donor brain death is associated with reduced renal allograft function after transplantation.
5/2011	Targeting complement activation in brain-dead donors improves renal function after transplantation.

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Marc A Seelen Research Topics

Disease

13	Brain Death (Brain Dead) 01/2021 - 11/2008
9	Inflammation (Inflammations) 01/2021 - 11/2008
9	Reperfusion Injury 01/2019 - 04/2008
5	Fibrosis (Cirrhosis) 01/2020 - 05/2012
5	Chronic Kidney Failure (Chronic Renal Failure) 01/2019 - 01/2012
4	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/2006 - 11/2003
3	Chronic Renal Insufficiency 01/2021 - 01/2017
3	Lupus Nephritis 12/2018 - 11/2003
3	Infections 01/2018 - 01/2006
2	IGA Glomerulonephritis (IGA Nephropathy) 11/2020 - 12/2018
2	Disease Progression 11/2020 - 01/2017
2	Renal Insufficiency (Renal Failure) 01/2019 - 03/2014
2	Proteinuria 01/2019 - 09/2012
2	Ischemia 01/2017 - 04/2011
2	Delayed Graft Function 06/2015 - 02/2012
1	Pneumonia (Pneumonitis) 01/2021
1	Lung Injury 01/2021
1	Hereditary Complement Deficiency Diseases 01/2021
1	Anemia 01/2019
1	Necrosis 01/2017
1	Neoplasms (Cancer) 04/2016
1	Renal Cell Carcinoma (Grawitz Tumor) 01/2016
1	Death (Near-Death Experience) 06/2015
1	Hypoxia (Hypoxemia) 06/2015
1	Postoperative Pain 09/2012
1	Acute-Phase Reaction 07/2011
1	Vasculitis (Vasculitides) 01/2009
1	Immune Complex Diseases (Immune Complex Disease) 09/2004
1	Albuminuria 09/2004
1	Autoimmune Diseases (Autoimmune Disease) 09/2004

Drug/Important Bio-Agent (IBA)

17	Complement System Proteins (Complement)IBA 01/2021 - 04/2005
6	LectinsIBA 01/2021 - 04/2005
4	Interleukin-6 (Interleukin 6)IBA 01/2021 - 07/2011
3	Complement C3 (C3 Complement)IBA 01/2019 - 04/2011
2	ProperdinIBA 01/2021 - 01/2019
2	Biomarkers (Surrogate Marker)IBA 11/2020 - 01/2017
2	Collagen Type I (Type I Collagen)IBA 01/2020 - 01/2017
2	Complement Membrane Attack Complex (Membrane Attack Complex)IBA 01/2019 - 07/2011
2	CreatinineIBA 01/2019 - 01/2017
2	Heparin-binding EGF-like Growth Factor (HB-EGF)IBA 05/2012 - 06/2010
2	Mannose-Binding Lectin (Mannan-Binding Lectin)IBA 07/2011 - 01/2006
2	AntibodiesIBA 09/2004 - 11/2003
2	AutoantibodiesIBA 09/2004 - 11/2003
1	E-SelectinIBA 01/2021
1	InterleukinsIBA 01/2021
1	Indicators and Reagents (Reagents)IBA 11/2020
1	nintedanibIBA 01/2020
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 01/2020
1	ferric carboxymaltoseIBA 01/2019
1	Saccharated Ferric Oxide (Venofer)FDA Link 01/2019
1	IronIBA 01/2019
1	Complement Factor B (Factor B)IBA 01/2019
1	Complement Inactivating AgentsIBA 12/2018
1	Collagen Type VIIBA 01/2017
1	EpitopesIBA 01/2017
1	Complement Receptors (Complement Receptor)IBA 01/2017
1	LY2109761IBA 01/2017
1	Proteins (Proteins, Gene)FDA Link 01/2017
1	Messenger RNA (mRNA)IBA 01/2017
1	Histones (Histone)IBA 01/2016
1	Oxygen (Dioxygen)IBA 06/2015
1	dicarboxydine (DCD)IBA 06/2015
1	Complement C3b (C3bi)IBA 04/2015
1	Blood Proteins (Serum Proteins)IBA 09/2012
1	Interleukin-4 (Interleukin 4)IBA 01/2012
1	salicylhydroxamic acid (SHAM)IBA 07/2011
1	Acute-Phase Proteins (Acute-Phase Protein)IBA 07/2011
1	Toll-Like Receptors (Toll-Like Receptor)IBA 04/2011
1	LigandsIBA 06/2010
1	Heparin (Liquaemin)FDA LinkGeneric 06/2010
1	ErbB Receptors (EGF Receptor)IBA 06/2010
1	Epidermal Growth Factor (EGF)IBA 06/2010
1	C-Reactive ProteinIBA 07/2009
1	ProcalcitoninIBA 07/2009
1	Isoantigens (Alloantigen)IBA 01/2009
1	Dopamine (Intropin)FDA LinkGeneric 11/2008
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2006
1	MannansIBA 01/2006
1	Biological ProductsIBA 01/2006
1	antiglomerular basement membrane antibodyIBA 09/2004
1	Nuclear Proteins (Protein, Nuclear)IBA 11/2003
1	DNA (Deoxyribonucleic Acid)IBA 11/2003

Therapy/Procedure

11	Transplantation 01/2019 - 04/2008
3	Renal Dialysis (Hemodialysis) 01/2021 - 01/2018
3	Catheters 01/2019 - 05/2011
3	Therapeutics 01/2017 - 03/2014
3	Kidney Transplantation 01/2017 - 07/2009
2	Renal Replacement Therapy (Therapies, Renal Replacement) 01/2017 - 03/2014
2	Nephrectomy 04/2016 - 09/2012
1	Tissue and Organ Harvesting 06/2015
1	Intravenous Administration 01/2006